glp 1 drugs definition GLP-1 receptor agonists π GLP-1 Drugs: An Overview
Description
In the STEP 1 semaglutide trial (Wilding et al., NEJM , 2021) and the SURMOUNT-1 tirzepatide trial (Jastreboff et al., NEJM , 2022), nausea affected roughly 44% of semaglutide patients and about 24% of tirzepatide patients at the maximum dose
Why does this matter for dosing
"DPP-4 Inhibitor-Induced Rheumatoid Arthritis Among Diabetics: A Nested Case-Control Study"
34 The AMPLITUDE-O trial demonstrated significant dose-dependent effects of efpeglenatide on HF hospitalisation in patients with T2D and CVD or renal disease, along with one risk factor
PubMed,
However, in terms of immune system effects, there is limited evidence indicating that DPP4 inhibition impairs immune function
