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In patients with T2DM who are poorly controlled by metformin, increasing DUL from 1.5mg to 3.0mg or 4.5mg can provide glycosylated hemoglobin and weight loss related to clinically relevant doses and has similar safety (111)

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Also, they have a favorable impact on Sertoli cell metabolism, which is important in the production of sperm (102)

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Top-line results of the phase 2 trial demonstrated metopimazine led to a 40% reduction in the incidence of nausea and a 56% reduction in frequency of vomiting

The project number is 201901D111383