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Mechanistically, FSH vaccination treatment inhibited lipid biosynthesis by inactivating PPAR adipogenic signaling pathway and simultaneously enhancing adipocyte thermogenesis via upregulating UCP1 (uncoupling protein 1) expression in both visceral and subcutaneous adipose tissues (74)
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Phendimetrazine a milder stimulant taken 2-3 times daily, helpful for those needing hunger control throughout the day
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Clinical outcomes such as cirrhosis progression, liver transplant, and all-cause mortality are recognized as solid endpoints for evaluating drug efficacy in MASLD
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