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In conclusion, GLP-1 RAs are an intriguing multitarget treatment option for people with NDs, and future research should focus on optimizing treatment for clinical trials, evolved agonists that can penetrate the central nervous system (CNS), and combination therapies.

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Overview: Tirzepatide is a dual agonist of the GLP-1 and GIP receptors for metabolic modulation

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Trevogrumab + Semaglutide: Phase2 data showed this combination reduced fat while protecting muscle, with patients losing ~11.3% of their body weight