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Description
The first group included patients treated with JAK inhibition who subsequently initiated treatment with GLP-1 receptor agonists

Zepbound (the same drug) is FDA-approved for obesity

The native GLP-1 peptide are not included in the Australian Register of Therapeutic Goods and cannot lawfully be supplied in Australia

Long-acting agents (semaglutide weekly, dulaglutide, tirzepatide) produce continuous but physiologically attenuated gastric slowing because of tachyphylaxis at the gastric GLP-1 receptor [3]

Bagherzadeh-Rahmani B, Marzetti E, Karami E, Campbell BI, Fakourian A, Haghighi AH, et al

Obesity As described above, overweight and obesity are far too prevalent, with roughly 75% of U.S
