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doi: 10.1056/NEJMoa1410489 Sabatine MS, Giugliano RP, Keech AC, Honarpour N, Wiviott SD, Murphy SA, Kuder JF, Wang H, Liu T, Wasserman SM, et al

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Ethical Statement This SRM followed the guidelines outlined in the Cochrane Handbook for Systematic Reviews of Interventions [21] and is reported in compliance with the Preferred Reporting Items for Systematic Reviews and MetaAnalyses (PRISMA) checklists [22]