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All GLP-1RAs [reviewed in (81)] and, more recently, the dual incretin receptor agonist tirzepatide, have been shown to lower postprandial triglyceride and ApoB-48 levels significantly (82)

Eur J Epidemiol (2014) 29(8):5419

Differences in dosing schedules, potency, receptor affinity, and pharmacokinetic profiles help explain these variations in clinical outcomes

The American Diabetes Associations position that metformin should remain the first-line treatment for most type 2 diabetes cases is partly driven by this cost advantage at roughly $120 per year versus over $11,000 annually for Rybelsus, metformins modest efficacy is justified for 90% of people starting type 2 diabetes treatment

however, first-time prescribing rates declined over the same period (-6.6%)