glp 1 is not working How GLP-1 weight loss medications work and their limitations When GLP-1 medications fail to
Description
8-12 weeks of consistent medicine usage may result in notable weight loss
The STEP trials are testing semaglutide at the higher dose of 2.4 mg/week (as compared to 1.0 mg/week for the original diabetes indication), specifically for promoting weight loss, regardless of the presence of type 2 diabetes

doi: 10.1002/ddr.21439

Neither insulin nor C-peptide were affected by exenatide treatment in this study
A realistic target for most GLP-1 users falls in the 20 to 25 gram range, with emphasis on reaching at least 15 grams even on difficult days
Diet and nutrition on GLP-1 GLP-1 medications suppress appetite significantly, which means nutrition becomes more important, not less