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Participants starting with an average weight of 113kg achieved: 20.7% weight loss with the 7.2mg weekly regimen 17.5% weight loss with 2.4mg once weekly 2.4% weight loss with placebo More patients reached substantial weight loss milestones on the higher weekly dose

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Furthermore, semaglutide inhibited apoptosis by increasing the Bcl-2/Bax ratio

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However, the exact role they play in the disease is unknown
