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We have not observed concerning signs of muscle weakness in clinical trials to date." The company said 11.3 percent of patients on the highest dose during retatrutide's clinical trial stopped taking the drug during the study because of significant side effects: nausea, diarrhea, constipation, vomiting and upper respiratory tract infection

17 The reductions in body weight and BMI observed with semaglutide were substantially greater than those reported among adolescents taking other glucagon-like peptide-1 receptor agonists and medications for obesity

Our guide to breaking a weight-loss plateau on Ozempic may be helpful

Can Semaglutide Be Used for Weight Loss if I Do Not Have Diabetes

discuss this risk with patients when initiating treatment and inform them of the key symptoms and signs that should prompt them to seek medical advice

Severe vomiting should be reported to your healthcare provider promptly