retatrutide mechanism triple agonist glp-1 gip glucagon receptor LY3437943, a novel glucagon, GIP, and for glycemic control and weight loss: From discovery to clinical proof of concept Retatrutide (LY3437943): Mechanism of Action

Insulinotropic hormone glucagon-like peptide-I(7-37) stimulation of proinsulin gene expression and proinsulin biosynthesis in insulinoma beta TC-1 cells

10.1111/dom.14922 11 OvergaardR

Zepbound is also an FDA-approved treatment for moderate to severe obstructive sleep apnea (OSA)

Dulaglutide versus insulin glargine in patients with type 2 diabetes and moderate-to-severe chronic kidney disease (AWARD-7): a multicentre, open-label, randomised trial

Glucagon-like peptide I increases cytoplasmic calcium in insulin-secreting beta TC3-cells by enhancement of intracellular calcium mobilization

This is one key difference between the two incretins