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Findings: RCTSURMOUNT-2 trial - Tirzepatide vs Placebo for Weight Loss in Diabetes, Lancet (2023) [PubMed abstract] Design: Randomized, placebo-controlled trial (N=938 | length = 72 weeks) in overweight diabetics (mean BMI 36 | mean A1C 8.02%) Treatment: Tirzepatide 10 mg once weekly vs Tirzepatide 15 mg once weekly vs Placebo Primary outcome: Coprimary endpoints were the percent change in body weight from baseline and body weight reduction of 5% or higher Results: Primary outcome (% reduction in weight): Tirzepatide 10 mg - 12.8%, Tirzepatide 15 mg - 14.7%, Placebo - 3.2% (p 35 - 68.9% Randomized treatment groups Group 1 (374 patients): Tirzepatide titrated to the maximum tolerated dose of 10 mg or 15 mg once weekly Group 2 (376 patients): Semaglutide titrated to the maximum tolerated dose of 1.7 mg or 2.4 mg once weekly Tirzepatide was initiated at a dose of 2.5 mg once weekly, and the dose was increased by 2.5 mg every 4 weeks until a maximum tolerated dose of 10 mg or 15 mg was reached

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The Best Strategy for Strong Results: GLP-1s Plus Lifestyle Changes A study presented at the AUA 2024 meeting 4 and published in the Journal of Urology explored the effects of GLP-1 receptor agonists on male reproductive health and impact of diet and lifestyle

A longitudinal study further demonstrated that type 2 diabetes in older community-dwelling individuals is associated with a decline in verbal memory and fluency over approximately 5 years ( The effects of diabetes on brain atrophy may begin as early as midlife

A meta-analysis of 5 RCTs 42,43,44,45,46 comprising 7,732 adults with T2DM did not observe any effect on cognition, as measured via mini-mental state examination (MMSE) or Montreal cognitive assessment (MoCA), of GLP-1RAs over several months compared with the baseline 38

Screening and Article Selection Two independent researchers screened titles and abstracts of all retrieved studies based on the eligibility criteria