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P value: two-sided P value from Fishers exact test for test of no difference

Structured Weight-Loss Findings Participants following the dosing regimen - in combination with caloric reduction, physical activity, and lifestyle counseling - demonstrated consistent and gradual reductions in body mass across 24, 48, and 68-week protocols

For most participants in trials, gastrointestinal symptoms were mild to moderate in severity and resolved over time

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But systemic estrogen levels also matter, and adipose tissue is a significant source of estrogen production through peripheral aromatase conversion

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