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This effect likely relates to delayed gastric emptying, as high-fat foods naturally slow digestion further, potentially causing discomfort or early satiety

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However, the clinical benefit of tapering versus abrupt discontinuation has not been formally studied for tirzepatide

Additionally, activation of GLP-1R has previously been demonstrated to induce IL-10 expression in chronic pain models [23], supporting the decisive role of GLP-1R in mediating the resolution of inflammation

Tirzepatide (Mounjaro/Zepbound) targets both GLP-1 and GIP receptors