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A pivotal 2021 clinical trial of semaglutide showed that participants lost an average of 15% of their body weight over 68 weeks, compared to just 2% in the placebo group

10.1097/HEP.0000000000000935 90 MillerD
This finding is in contrast to other studies in rats where similar changes in body fat and lean mass were seen after RYGB and VSG (39) and to other mouse models of VSG where differences in body mass over time are due solely to changes in fat mass (59, 82, 97)

Those factors could be contributing to the fact that people of color in the U.S

doi: 10.1038/379069a0 13 DunganKMPovedanoSTForstTGonzalezJGAtissoCSeallsWet al

Similarly, portal vein infusion of exendin 939 in rats has been shown to worsen glucose tolerance [41]
