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Our understanding of the biology of weight is evolving rapidly

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Individual responses can vary, making it important to choose high-quality products and start with small serving sizes

Although it is known that long-acting GLP-1 receptor agonists have diminishing effects on gastric emptying over time, subcutaneous semaglutide is reported to continue to delay gastric emptying, implying that it is less affected by tachyphylaxis [22]

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Retatrutide does not directly alter circadian rhythm, but the changes in eating patterns and metabolic activity can indirectly affect sleep-wake timing