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Overall, they are considered well tolerated for most people
The second important incretin hormone is GLP-1, released from L-cells in the distal ileum and colon (Gautier et al., 2008)

Talbot, K

Change in ONSD at M3 and M6 was not associated with the treatment group, but with ONSD at baseline (M3: \(\beta\)= 0.69, 95% CI 0.99, 0.39

Of the five lower limb muscles measured, only two showed statistically significant reductions, each in the range of roughly 10%

Among lean tissues, loss of liver mass exceeds change in muscle mass