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The prespecified selection criteria included: (1) RCTs reporting desired cardiovascular or renal outcomes

Bempedoic acid makes an appearance in the ADA Standards of Care

Kidney Int 97:202212 Gutzwiller J-P, Tschopp S, Bock A, Zehnder CE, Huber AR, Kreyenbuehl M et al (2004) Glucagon-like peptide 1 induces natriuresis in healthy subjects and in insulin-resistant obese men

For the primary endpoint at week 104, the authors report that in evoke, the mean CDR-SB change from baseline was 2.3 (SE 0.1) with semaglutide and 2.3 (0.1) with placebo, with an estimated between-group difference of 0.08 (95% CI 0.35 to 0.20

[3] Importantly, HCG is not a weight-loss medication

Retatrutide's Glucagon Component: An Additional Layer Unlike semaglutide and tirzepatide, retatrutide activates the glucagon receptor