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Interestingly, berberine activates AMPK by partially inhibiting mitochondrial complex I, which raises the AMP/ATP ratio inside cells a signal that tells the body, "energy is scarce, start burning fat." This is very similar to what happens during caloric restriction or exercise at the cellular level

These data are consistent with the T allele decreasing risk for T2D, as well as decreasing glucose and HbA1c levels, but slightly increasing the risk of smoking initiation (Supplementary Table 16)