glp-1 regain weight Two Years After Stopping GLP-1s, Most Patients Sustain at Least Some Loss GLP-1s work but when they're
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Data from the STEP 4 trial demonstrated that discontinuation of semaglutide typically results in return of appetite and substantial weight regain, indicating that for many individuals, ongoing treatment may be necessary to maintain benefits

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doi:10.1177/20420188251406456.
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These agents bind to GLP-1 receptors in tissues critical for glucose regulation, including pancreatic -cells (29)
