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4 A 2025 systematic review examining GLP-1 receptor agonists for depression found that several observational studies showed reduced depressive symptoms in people taking these medications, though results from randomised controlled trials were more mixed

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Therefore, GLP-1 has been extensively studied as a possible treatment of type 2 diabetes, and GLP-1 analogues and DPP-4 inhibitors are now widely in clinical use in these patients [711]

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10.1152/ajpendo.00492.2002