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The trial demonstrated that approximately 35% of semaglutide-induced weight loss was due to loss of lean mass and further demonstrated that combining semaglutide with trevogrumab with or without garetosmab helped preserve lean mass while increasing loss of fat mass

Female GLP-1RA users showed increased HSV risk (HR=1.51), and poorly controlled patients (HbA1c7%) had higher HSV risks (HR=1.195)

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At week 4, an 83% (11.1 U/day) reduction in TDD was due to a direct drug effect, and 17% (2.3 U/day) was attributed to weight loss, whereas at week 26, the difference was split evenly between direct effect (11.4 U/day

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