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Dose adjustments cannot compensate for untreated hormonal instability or ongoing muscle loss
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The H3K9me3 mark is deposited on the inactive X chromosome, contributing to its stable silencing and preventing the expression of the genes on that chromosome (Keniry et al., 2016)

Barnett, Future challenges and therapeutic opportunities in type 2 diabetes: hanging the paradigm of current therapy, Diabetes Obes

Some research has even found that using BMI to determine treatment may end up excluding a significant number of adults who have weight-related health conditions, such as metabolic syndrome
