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GLP-1 receptor agonists and cardiovascular outcome trials: An update

Ambery P, Parker VE, Stumvoll M et al (2018) MEDI0382, a GLP-1 and glucagon receptor dual agonist, in obese or overweight patients with type 2 diabetes: a randomised, controlled, double-blind, ascending dose and phase 2a study

Because toll-like receptor-4 (TLR4) is a receptor for LPS, subsequent experiments were conducted using TLR4 knockout (TLR4KO) mice

The SURMOUNT-1 trial formally assessed weight loss of tirzepatide against placebo in obesity

These results indicate that GLP-1R activation actively impedes fetal growth

A recent meta-analysis involving 32,884 patients from 19 randomized controlled trials further confirmed a 23% reduction in all-cause mortality associated with GLP-1RAs use (OR = 0.77) (Rivera et al., 2024)