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Appendix Table 1

The first and most notable distinction is the medications mechanism of action

They primarily function by blocking the enzyme DPP-4, which degrades GLP-1

They can help find solutions to minimize or ease symptoms, which may include lifestyle modifications, prescription or OTC medications, or keeping you at a lower medication dose until your body adjusts

Your monthly cost remains stable whether you're advancing, holding, or temporarily stepping backsupporting the principle that your dose may need to change, but your price won't

These effects are partially why physicians start semaglutide prescriptions with a low dosage, and gradually increase doses depending on tolerance