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Additionally, a recent open-label randomized trial showed that semaglutide significantly reduced serum IL-6 and CRP levels in PsO T2DM patients, compared to controls not on semaglutide therapy, reinforcing the anti-inflammatory effects of GLP-1RAs (45)

Aetna may not cover Mounjaro for weight loss as it is an off-label use

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Long-term users who experienced initial heartburn frequently report that it resolved completely by months 3 to 6

The lack of long-term clinical trials in weight management compels clinicians to consider potentially unforeseen long-term side effects of the GLP-1 receptor agonists

However, compounding pharmacies cannot guarantee efficacy beyond the stated expiration date, and PlexusDx recommends discarding any vial that has passed its printed expiration date