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14,15 Using the formula for comparing two means, with a two-sided = 0.05 and power = 80%: the minimum required sample size to detect a difference in HbA1c was 39 patients per group (78 total) and the minimum required sample size to detect a difference in BMI was 48 patients per group (96 total)

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Your dose may be too high for initial tolerance, or your provider may recommend starting even lower before gradually increasing

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M., Katz, H