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Unlike the transient and localized actions of endogenous GLP-1, GLP-1RAs maintain consistent levels across arterial, portal, and venous compartments
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You want to keep substances that are moving through the digestive tract soft, and then you can more easily have a comfortable bowel movement. Overall digestive health suffers
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So if you keep the body fat down, leptin stays down, and it seems to be regulating these other processes pretty well
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