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Research has shown that people taking semaglutide can lose a significant amount of lean mass alongside fat loss

doi: 10.1038/oby.2004.14 [DOI] [PubMed] [Google Scholar] 40.Crivelli JJ Mitchell T Knight J, et al

Most patients experience symptom improvement within two to three weeks as their body adapts to semaglutide's mechanism

Since the medication already reduces your appetite and slows digestion, consuming 4-6 small meals throughout the day (rather than two or three large ones) gives your stomach less work to do at once and reduces fermentation in your colon

But oral medication does not remove the need for medical supervision

The ipamorelin vs CJC-1295 comparison breaks down how these two are often paired together