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recently presented detailed Phase 2b results for berobenatide (PF3944), an investigational once-weekly and once-monthly GLP-1 receptor agonist, showing proof of concept for meaningful weight loss with low gastrointestinal side effects across obesity and type 2 diabetes populations

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Orlistat (Alli), Sibutramine (Meridia), and Rimonabant (Acomplia) emerged, but some were banned due to cardiovascular and mental health risks