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Despite this being prominent in the news, the first medication mentioned by GPs and IMs when asked Which drugs for managing of patients living with obesity are you aware of, even if you have not prescribed them? was, in 54% of responses, the much older and less effective orlistat and its brand names Xenical and Alli (figure 1)

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However, heterogeneous experimental designs and limited translational data necessitate further standardized and in vivo research to define clinical applications.