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In the SELECT trial that included over 17,000 patients with obesity and established CV disease, but without diabetes, weekly s.c

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On tirzepatide, reduced caloric intake means you have less available energy for intense exercise, so moderate effort is more appropriate than high-intensity training

doi: 10.1016/j.jacc.2024.05.057

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After 68 weeks of treatment, 68.8% of patients in the SC semaglutide 2.4 mg group lost 5% weight and 28.5% in the placebo group