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Pregnancy Outcomes: Some trials reported higher spontaneous pregnancy rates after several months of exenatide therapy compared with metformin monotherapy

Abrupt cessation creates a hormonal whiplash that makes weight regain almost inevitable

Long-term success depends on habits people can maintain

Conclusion Increasing evidence suggests that anti-diabetes medicine, GLP-1R agonists, have multiple neuroprotective mechanisms in AD models, such as anti-inflammation, anti-oxidative stress, reducing A aggregation/deposition and tau protein hyperphosphorylation, reducing neuronal apoptosis and neurotoxicity, increasing cell proliferation and neurogenesis, increasing synaptic plasticity, and other beneficial effects

You need a dose change

Although GLP-1 RAs have demonstrated efficacy even without structured behavioral support, their broader therapeutic potentialparticularly regarding long-term behavior change, psychological stabilization, and sustained weight lossmay be most effectively realized when embedded within a biopsychosocial framework