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Mark Turner, HSE assistant national director, said there was a strong suggestion that off-label prescribing to obesity patients was further challenging supplies of the drug, which is taken by regular injection

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Nonetheless, the tirzepatide effect of delayed gastric emptying was found to significantly reduce oral contraceptive PK by ~ 60% and, thus, the drug label advises patients using oral hormonal contraceptives to switch to or add a non-oral contraceptive method when initiating tirzepatide and after each dose escalation

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