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In total, 689 cases were selected for immunohistochemical analysis, which included 108 PanNETs, 18 gastric NETs, 59 duodenal NETs, 1 NET of papilla Vater, 8 small intestinal NETs, 1 appendiceal NET, 79 rectal NETs, 1 NET of gallbladder, 2 NETs of extrahepatic bile duct, 27 gastrointestinal NECs, 23 pulmonary NETs, 5 mediastinum NETs, 22 pulmonary NECs, 1 renal NET, 9 urinary NECs, 3 NEC of uterine cervix, 3 middle ear NETs, 11 olfactory neuroblastomas, 1 NEC of pharynx, 90 paragangliomas/pheochromocytomas, 4 CE-NETs, 26 medullary thyroid carcinomas (MTC), 53 parathyroid adenomas, 6 parathyroid carcinomas, 20 Merkel cell carcinomas, and 108 pituitary neuroendocrine tumors