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101 Despite major advances in the acknowledgment of tissue-specific NAD + homeostasis, further work will be needed to fully characterize the subcellular and systemic modulation of NAD + metabolism, which can improve the preventive and therapeutic strategies based on maintaining healthy NAD + homeostasis
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It started in the 80s, then fast forward 40 years later, GLP1 receptor agonists became one of the main drug classes in type 2 DM and obesity treatment, reducing MACE (Sattar et al, Lancet Diabetes Endocrinol
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