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These data support the use of lower, better-tolerated doses of GLP-1RAs to treat HFpEF, potentially benefiting a wider range of patients, including those who are not obese or who suffer from side effects with current GLP-1 regimens

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A recent Nature article on novel GLP-1 therapies underscores a truth few key opinion leaders in medicine like to focus on: Even the most clinically impactful pharmaceutical accomplishments carry serious and potentially deadly risks.

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