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doi: 10.1007/s10557-019-06915-8 90 VermaMKGoelRKrishnadasNNemmaniKVS

demonstrated in KO mice that the regulation of -cell number and function by GLP-1 depends on the cAMP/PKA mediated-induction of insulin-like growth factor-1 receptor (IGF-1R) expression and the increased activity of insulin-like growth factor 2 (IGF-2)/IGF-1R by an autocrine mode of action [25]

doi:10.1093/micmic/ozad102 Mieczkowska A, Millar P, Chappard D, Gault VA, Mabilleau G

In cardiomyocytes after CA, the number of inter-mitochondrial junctions (an index of highly active mitochondria) was significantly decreased, while empagliflozin treatment significantly increased the number of inter-mitochondrial junctions

Heart Failure: In 2013, the SAVOR-TIMI trial reported a significantly increased risk of hospitalization for heart failure (HF) in patients taking saxagliptin

Patients with cardiovascular (CV) risk, for instance, FDCs planned with sitagliptin and metformin or empagliflozin have shown superiority versus monotherapy on the grounds of treatment efficacy in clinical trials [29]