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GLP-1s have been shown to reduce inflammatory markers, which can help calm the inflammatory environment that contributes to pain and disease activity
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This triple-receptor mechanism distinguishes it from existing authorised agents such as semaglutide (GLP-1 agonist, available as Wegovy and Ozempic) or tirzepatide (GLP-1/GIP dual agonist, available as Mounjaro)

GLP-1, secreted by the intestine, brainstem, and pancreas, also exerts appetite-suppressing and gastric emptying-delaying effects on the hypothalamus

It's designed to fit a specific lock (its receptor) to trigger a biological action

Recommendations for daily water intake vary and depend on the individual, but the Institute of Medicine of the National Academies has set adequate intake levels at 2.7 liters (91 ounces [oz]) for women and approximately 3.7 liters (125 oz) for men