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The evolving public perception of obesity stigma reflects a gradual shift toward recognizing obesity as a complex medical condition influenced by biological and environmental factors, rather than a simple matter of personal responsibility

The first identified incretin was a gastric inhibitory peptide (GIP) with the activity of inhibiting the secretion of gastric acid, which was isolated from porcine small intestines ( + channel and depolarize the cell membrane, while also activate the voltage-dependent Ca 2+ channel, causing a Ca 2+ inflow and the generation of action potentials ( 2+ release by activating inositol triphosphate (IP3)

Although the present computational study provides three potential candidates as long-acting GLP-1 agonists, an experimental process needs to be established, a matter which is the theme of our ongoing study

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