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Glucagonlike peptide 1 receptor agonists and mental health: a systematic review and metaanalysis

Some people experience constipation only during the early weeks of starting or increasing their GLP-1 dose

Insulin signaling directly influences immune cell metabolism, macrophage polarization, and T-cell differentiation, thereby shaping inflammatory responses within musculoskeletal tissues ( Increasing evidence from immunometabolic research supports a bidirectional relationship between metabolic dysfunction and inflammatory arthritis, whereby chronic inflammation promotes insulin resistance, which in turn amplifies synovial and entheseal inflammation ( Figure 1 , insulin resistance, adipose tissue inflammation, and impaired incretin signaling converge at the skinjoint axis to amplify IL-23/IL-17driven immune activation and disease progression

77.5% in overweight and 93.9% in obese patients) [33]

PubMed CrossRef Carmellini P, Cuomo A, Rescalli MB, et al

February 1, 2024