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doi: 10.1016/j.metabol.2012.09.004

Complications Arising from Gastroparesis or Stomach Paralysis According to the National Institute of Diabetes and Digestive and Kidney Diseases, gastroparesis can lead to various complications, such as: Dehydration due to persistent vomiting Malnutrition due to inadequate absorption of nutrients Challenges in managing blood sugar levels Inadequate calorie consumption Formation of bezoars (solid masses of undigested food in the stomach) which can result in: Obstruction Ulcers Internal bleeding Reduced quality of life In severe cases, if a bezoar prevents food from passing into the small intestine, gastroparesis may become a life-threatening condition

The thing is, you cant maximize one side effect without maximizing all the dose-dependent side effects

Previous serious hypersensitivity reactions, current pregnancy (especially for weight-loss indications), active pancreatitis and severe gastroparesis generally contraindicate use

Angiopep-2-modified nanoparticles for brain-directed delivery of therapeutics: a review

30 Our results found that the increases in diabetes-specific and all-cause costs shown for the group taking GLP-1 RAs were largely attributable to the higher drug acquisition costs of the GLP-1 RAs