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Some researchers report worse nausea during the luteal phase (the two weeks before menstruation), when progesterone is already causing gastrointestinal symptoms

[1] [3] After injection, the pen should be discarded in an FDA-cleared sharps containerthere is no storage period after the pen has been used

Your provider should be guiding these decisions

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If more time has gone by, just skip that dose and return to your regular schedule

For storage guidelines, see our complete guide on tirzepatide refrigeration requirements and how long tirzepatide lasts in the fridge