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Also, preclinical studies have shown that the dual combination of GIP and glucagon (GCG) agonists has a more pronounced reduction in hepatic triglycerides and improvement in liver histological disease activity scores than GLP-1RA (liraglutide)

The figure connects the activation of GLP-1R to downstream pathways (cAMP/PKA, Epac/PI3K/Akt, AMPK/SIRT1, ERK/MAPK) that regulate mitochondrial function, autophagy, proteostasis, and stress response, all of which collectively influence the hallmarks of aging to improve both cellular and systemic resilience
The primary one is competition from other GLP-1 drugs, especially from Eli Lillys Mounjaro (tirzepatide), which has shown greater efficacy in weight loss and diabetes control

Novo Nordisk has already submitted an oral Wegovy (oral semaglutide) application

Fourth, pick three to four anchor foods you can eat reliably and rotate them: most patients land on Greek yogurt, eggs, deli turkey or chicken breast, and cottage cheese as the bedrock
