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Additionally, the self-reported nature of the study which might have imposed some bias to the results

GLP-1 drugs, especially the next-generation versions, are remarkably effective at helping people lose weight, Krause says

Clinical trials show average reductions of 2 to 5 pounds over 12 weeks when combined with dietary changes

Regarding pharmacodynamics, TZP appears as a biased GLP-1R-GIPR co-agonist, because of its positive effects on cAMP generation over -arrestin recruitment, which is conversely stimulated by GLP-1R

Weight loss was not only compared with a placebo group, but also to another substance in the GLP-1 receptor agonist class called Liraglutide