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doi: 10.1111/dom.15624 [DOI] [PubMed] [Google Scholar] 142.Maselli DB, Camilleri M

The most common side effects of tirzepatide are gastrointestinal: Nausea: Reported by 12-33% of participants depending on dose (most common early in treatment) Diarrhea: 12-21% of participants Constipation: 6-11% of participants Vomiting: 5-13% of participants Decreased appetite: Expected therapeutic effect but can be uncomfortable These side effects are typically most intense during the first few weeks at each new dose level and tend to improve as the body adjusts

doi: 10.1507/endocrj.EJ16-0449

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Science supports the first two claims, but the third, a supposed change in penis size, is the one that's capturing attention: "Ozempic penis" has become a breakout search term on Google in the past 30 days, surging more than 5,000% compared to the previous period

Clean hands are a must, so wash them thoroughly before you start