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Insulin was the first human protein manufactured using the method, approved for use in the treatment of diabetes in 1982

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doi: 10.1038/s41598-018-28496-6

Although skeletal muscle and the liver do not contain GLP-1 receptors, GLP-1 still influences these tissues indirectly via insulin and glucagon

Comparative effectiveness of GLP-1 receptor agonists on glycaemic control, body weight, and lipid profile for type 2 diabetes: Systematic review and network meta-analysis