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As of April 2026, retatrutide is understood to be progressing through Phase 3 clinical trials large-scale studies designed to confirm efficacy and safety before a medicine can be submitted for regulatory approval

Advise patients to discontinue JANUMET XR immediately and to promptly notify their healthcare provider if unexplained hyperventilation, myalgias, malaise, unusual somnolence or other nonspecific symptoms occur

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Third, long-term safety data remain limited, particularly for chronic glucagon receptor activation