retatrutide tingling sensation Two side effects are showing up more often with than with other GLP-1 medications like semaglutide or tirzepatide: (paresthesias) and itching (pruritus). Even though retatrutide is still in research and Retatrutide: The New Triple-Agonist Weight
Description
While these trials confirm the short-term effectiveness of the drugs, they highlight the need for caution regarding long-term weight maintenance

Pederson RA, Brown JC

INDIVIDUALIZED CARE

Ozempic and Wegovy function by mimicking GLP-1, a hormone that regulates appetite and food intake
In the semaglutide obesity study, 4.5% of participants in the treatment arm discontinued treatment due to gastrointestinal events

Given the success of incretin-based drugs in treating both diabetes and obesity, and their potential for treating NAFLD, further dissection of the regulation of hepatic metabolic pathways by DPP4 is warranted (2733)
