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Brand-name pen devices (Mounjaro/Zepbound): Unopened pens can remain at room temperature up to 86 degrees Fahrenheit (30 degrees Celsius) for up to 21 days

Severe nausea that does not resolve within the first 48 hours after injection is the most common indicator

Before using any vial, check three things

Months 7 through 12 (maintenance dose) Weight loss: 35 to 55+ pounds total

As use of antidepressants among an aging population continues to increase, and as physicians in multiple disciplines prescribe them for evolving indications (eg, duloxetine to treat osteoarthritis, diabetic neuropathy, fibromyalgia, and chemotherapy-induced peripheral neuropathy), healthcare providers need to be prepared to see more cases of serotonin syndrome and its deleterious effects